Hemolysis in newborns is a serious disease, and I believe no parent wants their child to suffer from such a disease. To know if their child will experience hemolysis, it is necessary to check their blood type, as certain blood types may cause hemolysis in newborns. So, does it require blood from both parties to check for hemolysis?
Does hemolysis require blood from both parties?
1. If it is necessary to check the hemolysis status of both parties, both parties need to be present. In general, different blood types are not the fundamental cause of hemolytic reactions. Related to genetic factors or abnormal immune system.
2. This disease is mainly a genetic disease type 2 hypersensitivity reaction caused by blood type incompatibility between mother and baby, resulting in blood type immune response. The dominant antigen inherited by the fetus from the parents is exactly what the mother lacks. This antigen enters the mother's body and produces immune antibodies (IgG) that can enter the fetal blood circulation through the placental chorion, bind to the surface receptors of fetal red blood cells, activate complement, and cause hemolysis, leading to anemia, edema, hepatosplenomegaly, and progressive severe jaundice in the short term after birth, and even bilirubin encephalopathy.
Does a mother with blood type O necessarily develop hemolytic disease?
1. When the mother has blood type O, the father has blood type A, B, or AB, and the fetus has blood type A or B, it is a mother son blood type incompatibility. If the mother has type O blood and the child has type A blood, the mother has type O red blood cells in her body, and the plasma contains antibodies against type A red blood cells. Through the placenta, the mother's anti-A antibodies enter the baby's body and react with the A antigen in the baby's type A red blood cells, resulting in hemolysis.
2. Mother son blood type incompatibility does not necessarily lead to hemolytic disease. The incidence of ABO blood type incompatibility is about 20%, but the actual occurrence of neonatal hemolysis is only less than 5%.
3. From another blood type classification perspective, if the mother is RH negative, the father is RH positive, and the fetus is RHA positive, it belongs to mother son blood type incompatibility, but the probability of RH blood type incompatibility is lower.
Does hemolysis require blood from both parties? Generally, both husband and wife need to go to the hospital for hemolysis testing. As hemolytic disease of the newborn can cause serious adverse consequences, it is best for couples to undergo relevant tests before giving birth. If there is a high risk of hemolytic disease of the newborn, preventive measures should be taken.
