The most important thing for expectant mothers during pregnancy is prenatal check ups. Through prenatal check ups, it is possible to determine whether the baby is healthy. If there are any issues with the baby during the examination, pregnant women will feel anxious, especially young pregnant women who may not understand certain things and may not know how to solve them if problems arise. So, what is the reason for low fetal DNA concentration?
If the concentration of fetal DNA is low, it may be due to insufficient fetal DNA isolated and extracted from the maternal blood. A new blood test can be performed to rule out the disease. In addition, Down syndrome screening is high-risk and the probability of getting sick is high, so it cannot be determined that it is Down syndrome. Further examination is needed. Amniotic fluid aspiration and non-invasive DNA testing can basically determine the health status of the fetus.
Fetal DNA testing is currently the most advanced method for screening pregnant women for Down syndrome. It uses the elbow vein blood of pregnant women, conducts relevant tests, and then performs large-scale genome sequencing to determine whether the baby is at risk of Down syndrome.
Due to the different constitutions of each pregnant woman, the concentration of fetal free DNA in the blood also varies, generally between 3% and 13%. If the concentration is below 3%, then the concentration being checked is not enough. If the concentration is below 5%, the accuracy of the test results is very low, so insufficient concentration is not entirely due to the fetus, but is closely related to the pregnant woman's physical condition. For example, insufficient examination cycles, high blood viscosity in pregnant women, and insufficient sample size during blood collection can all affect the detection concentration. In such cases, pregnant women can switch to a different examination method.
