The pentavalent vaccine, as the name suggests, is a preventive vaccine for five infectious diseases. The pentavalent vaccine can prevent five very serious diseases, so many people choose to inject their children with the pentavalent vaccine. But after receiving the pentavalent vaccine, there will be many adverse reactions. So, what are the adverse reactions after receiving the pentavalent vaccine?
The Council for International Organization of Medical Sciences (CIOMS) recommends using the following terms and percentages to grade the frequency of adverse drug reactions: very common (≥ 10%); Common (≥ 1% and occasional (≥ 0.1% and rare (≥ 0.01% and extremely rare (0.01%, including sporadic reports)).
(1) Systemic and injection site adverse reactions:
① Very common: fever (37 1～38℃) ; Pain, redness, and induration at the injection site.
② Common: Fever ≥ 38 ℃.
③ Occasional: Fever ≥ 39 ℃; Redness and swelling at the injection site ≥ 5cm.
④ Rare: Fever and lower limb edema (occurring within a few hours after receiving a vaccine containing Hib, accompanied by cyanosis or transient purpura, which can be relieved on its own without sequelae; sometimes accompanied by fever, pain, and crying, but without cardiovascular and pulmonary signs).
(2) Gastrointestinal disorders:
① Very common: vomiting.
② Common: Diarrhea.
(3) Metabolic and nutritional disorders: very common: loss of appetite.
(4) Neurological disorders: very common: drowsiness.
(5) Mental disorders:
① Very common: easily provoked, abnormally crying.
② Common: Sleep disorders.
In the Phase I clinical trial conducted in China, whether it was administering one dose to infants aged 18-24 months or administering basic immunization to infants aged 2 months, the results showed that no serious adverse events or severe reactions related to the vaccine occurred. In the Phase III clinical trial, regardless of whether the vaccination program was administered at 2-3-4 months of age or 3-4-5 months of age, the local adverse reaction rate and systemic adverse reaction rate of the pentavalent vaccine group were similar to those of the single vaccine control group, both at a lower level.
Although there may be many adverse reactions after injection of the pentavalent vaccine, these reactions are generally mild and will not affect the child's normal life, so these reactions are acceptable. Parents and friends do not need to be overly nervous.
